The Swiss-Polish Cooperation Programme (SPCP) launched a call for proposals to select sub-regional development projects as part of the Swiss contribution to the enlargement of the EU in 2008. Subsequently, out of 38 submitted proposals ten projects were selected. All of them addressed the potential of peripheral sub-regions consisting of several Gminas (communes). The proposals of the ten selected projects were developed into final Project Proposals in 2009 and 2010. After that, the Swiss Agency for Development and Cooperation (SDC) approved the projects in spring 2011 and physical implementation took place between 2011 and 2017 in the four poorest Polish regions (=Voivodeships) of Małopolskie, Lubelskie, Podkarpackie and Świętokrzyskie, all of them in the south-eastern part of Poland. SDC mandated the authors to analyse the experiences and lessons learned with the ten regional development programmes in 2017.